259. Parathyroid Hormone Gene Modified Mesenchymal Stem Cells for Hypoparathyroidism
نویسندگان
چکیده
منابع مشابه
Parathyroid hormone replacement in hypoparathyroidism
Hypoparathyroidism results from insufficient parathyroid hormone (PTH) to maintain normal serum levels of calcium and phosphate. Unlike most endocrine deficiency disorders, the current standard of treatment is not replacement with PTH but supplementation with calcium and vitamin D. Normal physiology cannot be fully restored with calcium and vitamin D, and long-term complications of this treatme...
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Hypoparathyroidism (HypoPT) is characterized by low serum calcium levels caused by an insufficient secretion of parathyroid hormone (PTH). Despite normalization of serum calcium levels by treatment with activated vitamin D analogues and calcium supplementation, patients are suffering from impaired quality of life (QoL) and are at increased risk of a number of comorbidities. Thus, despite normal...
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ypoparathyroidism-retardation-dysmorphism (HRD) syndrome (OMIM 241410), also known as SanjadSakati syndrome, is a rare autosomal recessive disorder characterized by hypoparathyroidism, growth failure, developmental delay, and characteristic facies. We describe the effective short-term use (tapered over 12 days) of recombinant parathyroid hormone (PTH) (teriparatide) in an unusual genetic condit...
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2015
ISSN: 1525-0016
DOI: 10.1016/s1525-0016(16)33864-3